Alkaline phosphatase (ALP)

Sample Type: Serum (red top) OR Heparin (green top).  

Test Code: BALP

If the sample cannot be analysed within 24 hours of collection, then it must be refrigerated and remain chilled for transport. Please do not freeze if serum remains in contact with RBC.

Stable:  7 days at 2-8 ^oC once separated.

Alkaline phosphatase is an enzyme present in cell membranes with highest activity in liver and bone.

ALP may be elevated due to accelerated bone growth in very young animals. 

In adult dogs, ALP is induced by cholestasis, endogenous Cushing's syndrome, or some medications, primarily corticosteroids but also phenobarbital and primidone. 

In adult cats, elevated ALP can be seen in association with hyperthyroidism and cholestatic liver disease, particularly hepatic lipidosis with lower sensitivity for other causes of cholestasis. 

ALP is considered insensitive and/or of less diagnostic value than GGT for assessing cholestatic disorders in horses and ruminants. 

Colormetric assay